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African swine fever virus (ASFV) is the causative agent of African swine fever. ASFV is a large double-stranded DNA virus which replicates in the cytoplasm of infected cells and is the only member of the Asfarviridae family.^[1] ASFV infects domestic pigs, warthogs and bushpigs, as well as soft ticks (Ornithodoros),which are likely vectors. ASFV is the only virus with a DNA genome that is transmitted by arthropods. The virus causes a lethal haemorraghic disease in domestic pigs. Some isolates can cause death of animals within as little as a week after infection. In all other species, the virus causes no obvious disease. ASFV is endemic to Sub-Saharan Africa and exists in the wild through a cycle of infection between ticks and wild pigs/bushpigs/warthogs. ASFV was first described after European settlers brought pigs into areas endemic with ASFV and as such is an example of an 'emerging infection'.

Reddening of the ears is a common sign of African swine fever in pigs.

The clinical symptoms of ASFV are very similar to classical swine fever virus and the two diseases normally have to be distinguished by laboratory diagnosis.

African swine fever was restricted to the continent that bears its name until 1957 when the disease was reported in Lisbon, Portugal. A further outbreak occurred here in 1960. Subsequent to these initial introductions the disease became established in the Iberian peninsula and sporadic outbreaks occurred in France, Belgium and other European countries during the 1980s. Both Spain and Portugal had managed to eradicate the disease by the mid 1990s through a slaughter policy. During the late 1970s ASFV crossed the Atlantic Ocean and outbreaks were reported in some Caribbean islands, including Cuba and the Dominican Republic. Major outbreaks of ASFV in Africa are regularly reported to the World Organisation for Animal Health (previously called l'office international des épizooties (OIE)). The most recent outbreak of ASFV outside of Africa started at the beginning of 2007 in Georgia (country) and has since spread to the neighbouring countries of Armenia, Azerbaijan and Russia.

The swelling around the kidneys and the muscle hemorrhages shown here are typical of pigs with African swine fever

The appearance of ASF in the Western hemisphere at the same time as the emergence of AIDS led to some interest in whether the two were related and a report appeared in the Lancet supporting this in 1986. However, AIDS is now known to be caused by human immunodeficiency virus (HIV), no link between ASFV and AIDS has been proven or is suspected.

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